The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells.

Regression analysis shows that there is a significant trend toward increased levels of late apoptosis and total apoptosis with increasing statin concentration (Linear regression: p = 0.012 (r = 0.79) and p = 0.019 (r = 0.75) (late and total apoptosis for lovastatin), p = 0.003 (r = 0.86) and p = 0.044 (r = 0.46) (late and total apoptosis for mevastatin), p = 0.014 (r = 0.77) and p = 0.038 (r = 0.69) (late and total apoptosis for simvastatin)).

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A p-value < 0.005 was deemed highly significant.

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