Expression of small breast epithelial mucin (SBEM) protein in tissue microarrays (TMAs) of primary invasive breast cancers.

Furthermore, SBEM expression showed a trend towards an association with reduced overall survival and relapse-free survival in the ER+ cohort ( P = 0.063 and P = 0.072, respectively).

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However, in ER+ breast cancers a definite trend toward significance between SBEM protein levels and disease outcome of patients was observed, suggesting that SBEM may be associated with worse survival and shorter time to progression in this specific subgroup.

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Interestingly, even though no association existed between overall survival and SBEM expression ( Figure 4A ), a trend toward significance was observed for those breast cancers that exhibited high levels of SBEM positivity and a shorter time to disease progression, compared with those that were SBEM− [low levels, P = 0.057, n = 300, hazard ratio (HR) 0.65, 95% CI of ratio 0.37, 1.04; Figure 4B ].

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However, using the log rank test to generate Kaplan–Meier curves, an interesting trend toward significance was observed in disease outcome (OS and RFS), with patients with higher SBEM levels being associated with worse survival and a shorter time to progression ( P = 0.063, HR 0.461, 95% CI of ratio 0.117, 1.060; and P = 0.072, HR 0.522, 95% CI of ratio 0.172, 1.078, respectively; Figure 4E,F ).

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