Differences in muscle protein synthesis and anabolic signaling in the postabsorptive state and in response to food in 65-80 year old men and women.

Phosphorylated eEF2 Thr56 in muscle was ∼40% less ( P <0.05) in women than in men both during postabsorptive conditions and feeding ( Figure 2 ); there was a tendency for a decrease in the phosphorylation of eEF2 Thr56 in both sexes with feeding ( Figure 2 ) but this difference did not reach statistical significance ( P = 0.103). mRNA expression of proteins involved in the regulation of muscle mass The mRNA concentrations of myostatin and myoD during postabsorptive conditions were not different in men and women ( Figure 3 ).

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