Specifically, among the seven serotypes included in the conjugate vaccine, although most serotypes are indeed associated with the presence of the pilus locus (4, 6B, 9V and 14), serotype 23F was significantly depleted of the presence of this locus, indicating that an association with the presence of the pilus locus is not a property of all vaccine serotypes, while serotypes 18C and 19F did not reach statistical significance.
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The presence of the pilus locus is a clonal property among pneumococcal invasive isolates.
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