showed a trendp = 0.058
Using the UK dataset, reduced survival was significantly associated with a higher Ann Arbor disease stage (hazard ratio (HR) at treatment initiation 2.59 per stage increase by 1, 95% CI 1.45–4.66, p = 0.001) and showed a trend towards association with age (HR 1.02 per year of age, CI 1.00–1.04, p = 0.058) and RDI ≤ 90% (HR 1.42, CI 0.88–2.28, p = 0.146).