FOXP3+ Tregs and B7-H1+/PD-1+ T lymphocytes co-infiltrate the tumor tissues of high-risk breast cancer patients: Implication for immunotherapy.

Results A co-existence of B7-H1 + T lymphocytes and FOXP3 + T regs was evidenced by the highly significant correlation of these molecules ( P < .0001) and their expression by different T lymphocyte subsets was clearly demonstrated.

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There was also a correlation with large tumor size with a borderline significance ( P = .072) (Table 1 ).

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Intratumoral FOXP3+ T regs were found also to be associated with progesterone receptor negative status and lymph node metastasis although they did not reach statistical significance (Table 1 ).

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