Association of dopaminergic pathway gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes.

BMC Genet · 2008 · PMC2287188 · PMID 18366720

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highly significantno p-value reported

DRD2 Of the three polymorphisms analysed in this gene, we observed a highly significant allelic and genotypic association of - 141 ins/del C and G>A (1 kb upstream from exon 2) SNPs.

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a strong trendno p-value reported

Out of four SNPs tested in COMT gene only 900 ins/del C showed a strong trend towards genotypic association (Table 2 ), with insC/delC genotype being predisposing (OR 1.66, CI 1.09–2.52) towards CRI.

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