IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5'-6'-epoxyeicosatrienoic acid.

S4, available at http://www.jcb.org/cgi/content/full/jcb.200712058/DC1 ), although it did not reach statistical significance compared with 1 nM 5′,6′-EET + 30 μM IP 3 ( Fig. 6 H ) or 100 nM 5′,6′-EET alone (Fig.

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