type, located completely within intron 2 (designated “Block 2” in the publication), had an odds ratio of 4.18 for nonresponse ( P = .012) [ 104 ]. In addition, the most common haplotype within a haplotype located in the 3′ untranslated region of PPARG (designated “Block 5” in the publication) had a borderline significant odds ratio of 0.51 for response ( P = .049) [ 104 ]. 4.
In LOCAT, PPARA IVS7 2498 (designated “PPARA intron 7 G/C polymorphism” in the publication) C allele carriers had a significantly greater progression of coronary atherosclerosis compared with GG homozygotes [ 50 ]. No pharmacogenetic interaction was noted [ 50 ]. When the association of PPARA IVS7 2498 polymorphism with coronary atherosclerosis was investigated in 3,012 healthy middle-aged men in NPHS2, PPARA IVS7 2498 CC homozygotes showed a trend toward greater incidence of ischemic events (myocardial infarction (MI) or coronary revascularization) (HR 1.83; 95% CI 0.96–3.51; P = .07) compared to PPARA IVS7 2498 CG heterozygotes and PPARA IVS7 2498 GG homozygotes [ 50 ]. 2.4.2.