In these studies, a clear trend was observed that the tumors which preserve epithelial morphology, classified as undiffer- entiated type, express high amounts of cadherins, whereas the tumors which exhibit scattered morphology, classified as undifferentiated type, have reduced amounts of these mole- cules.
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Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts.
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