PROactive 07: pioglitazone in the treatment of type 2 diabetes: results of the PROactive study.

Vasc Health Risk Manag · 2007 · PMC2291341 · PMID 17969365

Europe PMC

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a clear trendno p-value reported

However, the UKPDS showed a clear trend towards a reduction in primary macrovascular events (based on a secondary endpoint of fatal/non-fatal MI) in patients whose hyperglycemia was more intensively managed with pharmacologic therapy (using sulfonylureas or insulin) compared with conventional management using lifestyle interventions ( UKPDS33 1998 ).

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