nominally significantP = 0.62
The nominally significant associations of the upstream variants rs1338625 and rs6426870 were not supported by the combined analysis (P = 0.62, OR 0.98 [95% CI 0.92–1.05]; P = 0.82, OR 0.99 [95% CI 0.93–1.06], respectively); while the negative result for rs4657364 was confirmed (P = 0.45, OR 1.03 [95% CI 0.95–1.12]) (Tables S5-7, Additional file 1 ).