Housekeeping genes tend to show reduced upstream sequence conservation.

These scores are comparable to those obtained previously (Table 1 ) and the differences between HK and non-HK genes were highly significant ( p < 10 -4 ; Figure 2 , top row, middle).

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In contrast, in CpG- genes the differences between HK and non-HK genes were smaller, and did not reach statistical significance in the mouse gene dataset (Figure 2 , top row, right).

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