Aryl hydrocarbon receptor nuclear translocator (ARNT) gene as a positional and functional candidate for type 2 diabetes and prediabetic intermediate traits: Mutation detection, case-control studies, and gene expression analysis.

ARNT SNPs and insulin secretion Based on the proposed role of ARNT in insulin secretion [ 3 ], we selected 4 SNPs that showed a trend to an association with type 2 diabetes or that had a minor allele frequency over 10% to test in two populations of nondiabetic European American individuals who had undergone detailed phenotyping of insulin sensitivity and secretion.

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