Low-dose mistletoe lectin-I reduces melanoma growth and spread in a scid mouse xenograft model.

Low-dose ML-I treatment (30 ng per kg body weight) reduced the apoptotic rate compared to the control group (15.74% apoptotic DCs vs 18.59%), which, however, did not reach statistical significance ( P >0.05).

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Previous in vitro experiments have already demonstrated a highly significant antiproliferative effect of ML-I on malignant melanoma cells, which is due to the induction of apoptosis ( Thies et al , 2005 ).

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