Use of NSAIDs, smoking and lung cancer risk.

Current smokers who had an estimated cumulative tobacco consumption of 1–14, 15–29 and 30 or more pack-years had highly significant 5-fold, 12-fold and 29-fold increased risks, respectively, compared to study subjects who had never smoked.

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Using objective pharmacy records, we observed a significant trend of decreasing risk with increasing numbers of prescriptions, with a 50% reduction those among those with at least four NSAID prescriptions per year 1–3 years before the index date.

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