Alteration of the serum levels of the epidermal growth factor receptor and its ligands in patients with non-small cell lung cancer and head and neck carcinoma.

TGF- α levels did not change significantly in NSCLC and HNC but showed a trend to higher levels, consequent with reports confirming increased serum TGF- α in ovarian ( Chien et al , 1997 ), hepatocellular ( Tomiya and Fujiwara, 1996 ; Harada et al , 1999 ), colorectal ( Shim et al , 1998 ), gastric ( Moskal et al , 1995 ; Choi et al , 1999 ) and breast cancer ( Chakrabarty et al , 1994 ) as measured by RIA.

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