The Wnt pathway regulator DKK1 is preferentially expressed in hormone-resistant breast tumours and in some common cancer types.

Finally, although it did not reach statistical significance, DKK1 expression was also documented in some of the most aggressive tumours, namely, in 39% of poorly differentiated histopathological grade 3 tumours and in 31% of tumours wider than 2 cm in their greatest diameter (data not presented).

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