Breast cancer tumours in TGFBR1 * 6A carriers were also slightly more poorly differentiated, indicating that the TGFBR1 * 6A variant might be associated with tumour grade even though our material of grade III tumours ( n =75), from the population-based cohort, is small and the association of borderline significance only.
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TGFBR1(*)6A and Int7G24A variants of transforming growth factor-beta receptor 1 in Swedish familial and sporadic breast cancer.
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The frequency of the Int7G24A variant in low-risk familial and sporadic breast cancer cases was higher compared to the controls, the OR for Int7G24A carriers and GA homozygotes and AA homozygotes as well, but the difference did not reach statistical significance.