Association of 12 serum biochemical markers of angiogenesis, tumour invasion and bone turnover with bone metastases from breast cancer: a crossectional and longitudinal evaluation.

Br J Cancer · 2006 · PMC2360666 · PMID 16880790

Europe PMC DOI

hedged sentences

0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

did not reach statistical significanceP =0.08so close (0.05 < p ≤ 0.1)

Serum TRACP5b levels were on average 95% higher in patients who will develop bone metastases compared to levels in patients who did not develop bone metastases although the difference did not reach statistical significance ( P =0.08).

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borderline significantno p-value reported

The increase in the biochemical markers was higher in patients who progressed toward bone metastases when compared to those who did not, although the difference reached statistical significance only for MMP-7, TIMP-1 and ICTP and was borderline significant for bone ALP ( Figure 5 ).

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