Barely Significant
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Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing.

Br J Cancer · 2006 · PMC2361183 · PMID 16449996

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showed a trendP =0.05actually significant
However, methylation at the CYCA1 gene promoter showed a trend for lower Anneroth score ( Anneroth et al , 1986 ), a histological grading system (Spearman's rank: ρ =−0.253, P =0.05, but multiple correlations made this NS).

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