Evaluation of ER, PgR, HER-2 and Ki-67 as predictors of response to neoadjuvant anthracycline chemotherapy for operable breast cancer.

A nonsignificant trend towards higher cell proliferation in pathologically node-positive tumours was observed (pathologically node negative, median Ki-67 19.6%, node positive 25.8%; P =0.09).

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In contrast with previous reports ( Bonadonna et al , 1990 ; Bottini et al , 1996 ; Chang et al , 1999 ; Colleoni et al , 2000 ), clinical response rates to PST were higher in hormone receptor-positive tumours in this cohort, although the difference did not reach statistical significance.

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