Plucked human hair as a tissue in which to assess pharmacodynamic end points during drug development studies.

It can be seen by comparing corresponding cells in Table 4 that, even when the hair stage effect is highly significant (e.g. total pRb – P <0.001 for stage difference), the improvement in intrasubject CV due to the stage adjustment is modest, with a greater impact on intersubject CV, perhaps reflecting a greater variation in the distribution of stages between subjects.

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Given the caveat that there were often small numbers of hairs present within each stage, while there was a difference in some marker levels between hairs at different stages, the pattern was not entirely consistent across all markers, and, in the majority of cases, failed to reach statistical significance (data not shown).

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