Microsatellite instability in colorectal cancer is associated with local lymphocyte infiltration and low frequency of distant metastases.

The increased frequency of metastases in MSS T3 cases was highly significant (Fisher's exact test: P <0.001, Table 4 ).

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Here, a clear trend towards fewer metastases in CLR positive cases was observed.

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Salahshor et al (1999) found an obvious trend towards a better outcome of their MSI-H collective, but this was not statistically significant.

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