Loss of heterozygosity is related to p53 mutations and smoking in lung cancer.

A highly significant association between p53 mutations and deletions on 3p, 5q, 9p, 11p and 17p was found.

also in 132,142 other papers

Other pathways such as recom- bination have also been reported to be involved in induction of LOH in normal human cells (Gupta et al, 1997) and loss of both alleles of p53 in a primary human glioblastoma tumour and cell line (Albertoni et al, 1998). For all loci examined (except 7p), there was a clear trend of higher occurrence of LOH in smokers than non-smokers.

also in 19,460 other papers