Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients.

Breast Cancer Res · 2008 · PMC2374953 · PMID 18182100

Europe PMC DOI

hedged sentences

0.3800

closest p · 7.6× alpha

0.3800

boldest claim

The sentences

a negative trendp = 0.380not close (p > 0.1)

Amplification of HER1 caused a negative trend for survival (HR = 1.24 (95% CI 0.77 to 2.00), p = 0.380), whereas HER4 resulted in a decrease in the HR (HR = 0.36 (95% CI 0.06 to 2.36), p = 0.289).

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a positive trendno p-value reported

Results We retrospectively found HER3 gene amplification with a univariate negative impact on disease-free survival (hazard ratio 2.35, 95% confidence interval 1.08 to 5.11, p = 0.031), whereas HER4 amplification showed a positive trend in overall and disease-free survival.

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