Accumulation of uPA-PAI-1 complexes inside the tumour cells is associated with axillary nodal invasion in progesterone-receptor-positive early breast cancer.

As can be seen from their univariate analysis, they found a highly significant ( P <0.0001) association between uPA–PAI-1 complexes and a tumour size of 2 cm or less.

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Any degree of uPA–PAI-1 complex accumulation inside the tumour cells showed a trend towards a significant association with nodal metastasis.

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In conclusion, the detection of uPA–PAI-1 complexes inside the tumour cells in early (T1) breast cancers expressing progesterone receptors is associated with a significantly higher incidence of axillary metastasis, and this might be of clinical value at the present time, where there exists an increasing trend towards avoiding axillary dissection at all in the presence of very small breast cancers with clinically negative axillae.

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While the number of ER+PR− tumours giving rise to this hypothesis was comparatively small (19 out of 189), the OR associated with uPA–PAI-1 was remarkably similar to the one observed among patients without hormonal receptors and neither of them was close to being statistically significant.

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