A K trans reduction of approximately 30% ( P <0.001) was evident with 50 and 100 mg kg −1 ZD6474, a reduction of 12.5% ( P <0.05) at 25 mg kg −1 , and a reduction that did not reach statistical significance at 12.5 mg kg −1 .
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Use of dynamic contrast-enhanced MRI to evaluate acute treatment with ZD6474, a VEGF signalling inhibitor, in PC-3 prostate tumours.
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Interestingly, ZD6474 has also demonstrated a highly significant effect on tumour growth and metastasis in this particular model ( Drevs et al , 2002b ).