a significant trendP < 0.001
Compared with controls, mean IGFBP-2 SDS were significantly elevated in patients with Dukes B ( P < 0.001), Dukes C ( n = 13 P < 0.001) and advanced disease ( n = 42 P < 0.0001), with a significant trend from early to advanced disease (one-way ANOVA P < 0.001).