Changes of bone turnover markers and serum PTH after night or morning administration of zoledronic acid in breast cancer patients with bone metastases.

Br J Cancer · 2008 · PMC2410114 · PMID 18506177

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a significant trendno p-value reported

Yet analysis of the decremental curves for serum CTX and urinary DPD yielded a significant trend towards greater antiresorptive effect in the group of patients receiving the drug at night.

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