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Intact and total insulin-like growth factor-binding protein-3 (IGFBP-3) levels in relation to breast cancer risk factors: a cross-sectional study.

Breast Cancer Res · 2008 · PMC2481489 · PMID 18471292

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Negative associations of intact (mean absolute breast density = 48.2, 46.0, 47.0, and 46.7 cm 2 ; r = -0.010; P = 0.79), fragmented (mean absolute breast density = 49.3, 48.3, 46.6, and 43.7 cm 2 ; r = -0.092; P = 0.01), and total (mean absolute breast density = 50.2, 49.4, 45.0, and 43.3 cm 2 ; r = -0.094; P = 0.01) IGFBP-3 levels with absolute breast density were observed before adjusting for confounders, although the association between intact IGFBP-3 levels and absolute breast density did not reach statistical significance.

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