Analysis of heterogeneity and epistasis in physiological mixed populations by combined structural equation modelling and latent class analysis.

Although very few gene variants were directly associated with metabolic syndrome in the total study sample, almost one third of all possible epistatic interactions were highly significant.

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When the epistasis analysis was corrected for multiple testing corresponding to analysis of 30 SNPs (as performed above), the original number of nominally significant two-SNP interactions was reduced to 70%.

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