Selective constraints in experimentally defined primate regulatory regions.

PLoS Genet · 2008 · PMC2490716 · PMID 18704158

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closest p · 1.4× alpha

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only marginally significantP<0.07so close (0.05 < p ≤ 0.1)

Summing over both coding and noncoding sites, we also find that mean selective constraint is also reduced somewhat in humans, compared with chimpanzees (0.254 versus 0.279), although this difference is only marginally significant (Bootstrap t-test, P<0.07).

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