Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer's disease.

Decrease in proliferation rate with age was quite significant: at 6 months of age in both sexes the proliferation rate was reduced by more than 60% when compared to the 2 months old animals (males 2.64±0.23 vs. 6.61±1.74; females 1.48±0.39 vs. 7.46±0.45, Fig. 1E–H ).

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