Pancreatic duct cells in human islet cell preparations are a source of angiogenic cytokines interleukin-8 and vascular endothelial growth factor.

Duct cell–induced allantoic vessel formation was reduced by 55 and 41%, respectively, in presence of an antibody against human VEGF or against human IL-8 but not by an antibody against human CXCL1 (95% of control, n = 3, data not shown); when expressed in absolute number of vessels these reductions did not reach statistical significance probably as a result of the large variation in the amplitude of IL-8 and VEGF release (section 1) and the related duct cell effects ( Fig. 3 ).

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