Efficacy of Carraguard-based microbicides in vivo despite variable in vitro activity.

For instance, additional post-hoc survival analyses in the Phase III clinical trial of Carraguard based on behavior, other risk factors, and adherence levels revealed that HIV incidence continued to be lower in the Carraguard group among the women who used the gel during 100% of sex acts, although this also did not reach statistical significance (Robin Maguire, personal communication).

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