CYP1B1 variants are associated with prostate cancer in non-Hispanic and Hispanic Caucasians.

Association of SNPs with PCa risk or disease aggressiveness When each of the SNPs was analyzed separately, age-adjusted logistic regression analysis demonstrated that Hispanic Caucasian carriers of the GG genotype when compared with the CC genotype showed a marginally significant decreased risk for PCa (OR = 0.31, P = 0.04, 95% CI = 0.10–0.96; Table IV ).

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This inflates the probability of a false discovery above the nominal P value, and tests of marginal significance should be interpreted cautiously given the number of hypotheses tested.

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