[11C]CHIBA-1001 as a novel PET ligand for alpha7 nicotinic receptors in the brain: a PET study in conscious monkeys.

Uptake of radioactivity (during 70–91 min) in the brain regions except the cerebellum (low receptor density) after intravenous administration of [ 11 C]CHIBA-1001 was decreased by pretreatment with SSR180711 (5.0 mg/kg) although these differences failed to reach statistical significance because of small number (n = 3) of monkey ( Figures 7A ).

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