HLA-driven convergence of HIV-1 viral subtypes B and F toward the adaptation to immune responses in human populations.

The four mutations were found not to have dominated HIV variants sequenced from the early epidemic in one of either B or F subtypes, three of them showing a significant trend in time ( p <0.05, Chi -squared for trend, Table 2 ) toward an increase in their prevalence.

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Remarkably, only one of them (mutations at position 30 in subtype F) was found to have a decreasing trend in time, although it was not significant ( p = 0.106).

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