Reply: Population change, population mixing and incidence of childhood acute lymphoblastic leukaemia in England and Wales

There was a highly significant positive trend linking quintile categories of 1991 : 1981 population ratio and diversity of origins of all-ages immigrants ( χ 2 =215.6 on 1 df, P <0.0001).

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As stated in the Results, in the multivariate analysis, there was a significant trend in incidence at ages 1–4 years in relation to the diversity of total incomers, and incidence was higher in rural wards than in those classified as urban or mixed.

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