Barely Significant
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NPHS2 variation in focal and segmental glomerulosclerosis.

BMC Nephrol · 2008 · PMC2569023 · PMID 18823551

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The homozygotes with p.R229Q had a 2.15 fold increase of developing proteinuria or ESRD but this did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.