Pharmacokinetic and pharmacogenetic determinants of the activity and toxicity of irinotecan in metastatic colorectal cancer patients.

Br J Cancer · 2008 · PMC2570505 · PMID 18797458

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.2000

boldest claim

The sentences

highly significantP <10 −7actually significant

A highly significant correlation existed between the AUC values of APC and NPC ( r =0.857, P <10 −7 ).

also in 132,142 other papers

weakly significantP =0.03actually significant

There was a weakly significant correlation between the dose administered and the AUC values of irinotecan and SN-38 ( r =0.311 and 0.265, respectively, P =0.03 and 0.07).

also in 1,387 other papers

failed to reach significanceP =0.20not close (p > 0.1)

The relationship between UGT1A1 polymorphism and SN-38G AUC value especially failed to reach significance ( P =0.20).

also in 4,113 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.