Euglycemic hyperinsulinemia alters the response to orthostatic stress in older adults with type 2 diabetes.

First, older subjects with type 2 diabetes demonstrated no significant difference in total peripheral resistance during upright tilt in the high-dose insulin session (there was a nonsignificant trend toward lower total peripheral resistance, as shown in Fig. 3 ).

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Presyncope during euglycemic-hyperinsulinemic upright tilt was possibly due to a decrease in total peripheral resistance (although this did not reach statistical significance) or to an impaired tachycardic response to tilt-induced hypotension.

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