Experimental observations of rapid Maize streak virus evolution reveal a strand-specific nucleotide substitution bias.

We found that G→T transversions were over-represented in both the maize and sugarcane evolution experiments, and that this over-representation was highly significant when either the MSV-Tas sequence dataset was analysed alone (chi square p < 10 -8 ) or when all the mutation data from both experiments were considered collectively (chi square p = 5.4 × 10 -7 ; Table 1 ).

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Probably as a consequence of the high rate of G→T mutations, there was evidence of a significant trend towards lower GC content over the course of the evolution experiments when all mutations were collectively considered (chi square p = 0.05).

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