Genes responsive to both oxidant stress and loss of estrogen receptor function identify a poor prognosis group of estrogen receptor positive primary breast cancers.

Breast Cancer Res · 2008 · PMC2575534 · PMID 18631401

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0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

did not quite reach statistical significanceP = 0.07so close (0.05 < p ≤ 0.1)

The subset with higher (H) expression of proliferation genes was associated with significantly higher Ox, Ox', and Ox-E/ER indices ( t -test, P < 0.05) relative to the subset with lower (L) expression of proliferation genes (Figure 2b ); the trend for H tumors to have a higher Ox'-E/ER index did not quite reach statistical significance ( P = 0.07).

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a strong trendno p-value reported

A strong trend was observed for enrichment of oxidant-repressed Ox-E/ER genes (such as Bcl2) in ER-positive/PR-positive tumors, reflecting their suppression in ER-positive/PR-negative tumors (FWER, P = 0.07).

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