Barely Significant
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Bones and Crohn's: estradiol deficiency in men with Crohn's disease is not associated with reduced bone mineral density.

BMC Gastroenterol · 2008 · PMC2577678 · PMID 18947388

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The difference in E2 and T serum levels of current CS users and CS non-users did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.