The levels of ROS/RNS and superoxide were significantly elevated in all three knockout genotypes compared to the wild type controls, except for the ROS/RNS levels in the SOD-1/3 null genotype where the difference did not reach statistical significance, which is likely due to the small number of specimens ( Figure 2 ).
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Corneal endothelial integrity in aging mice lacking superoxide dismutase-1 and/or superoxide dismutase-3.
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