Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5.

For metoprolol, although a 2.7-fold increase of the terminal half-life was found in HBN mice, this did not reach statistical significance ( p = 0.1).

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For all fluorocoumarin substrates employed, there was a highly significant decrease in NADPH-mediated P450 metabolism in liver microsomes from the HBN mice (as high as 90% for EFC), whereas for the two resorufin analogues and bufuralol, the change was still significant (at least 50% decrease for each compound) but less marked.

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