Preoperative bevacizumab combined with letrozole and chemotherapy in locally advanced ER- and/or PgR-positive breast cancer: clinical and biological activity.

When the analysis was performed according to the menopausal status, this association was maintained with a borderline significance in premenopausal patients (140 vs 122 days, P =0.056), whereas it was completely lost in postmenopausal patients (191 vs 181 days, P =0.45).

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When we analysed the correlation of biological parameters with clinical response, we observed that higher levels of baseline CEPs were positively correlated with the likelihood of obtaining a clinical response ( P =0.026) ( Figure 3 ) and showed a trend towards the prediction of a Ki67 decrease >80% ( P =0.08).

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