Activation of a dendritic cell-T cell axis by Ad5 immune complexes creates an improved environment for replication of HIV in T cells.

In contrast, a highly significant (P < 0.001) approximately threefold difference was found in the percentage of total cytokine-secreting Ad5-specific CD8 T cells stimulated with Ad5 IC–treated DCs compared with Ad5 vector–treated DCs ( Fig. 4 a ).

also in 132,142 other papers

We next determined the effects of Ad5 IC on the proliferation capacity of Ad5-specific memory T cells and consistently observed a trend toward increase proliferation (about twofold) of CD4 and CD8 T cells stimulated with Ad5 IC–treated DCs, although these differences did not reach statistical significance (P > 0.05; Fig.

also in 111,027 other papers